"Mesakol": faatonuga mo le faaaogāina, counterparts moni

Ulcerative colitis ma faamaʻi o le Crohn ua matauina i gasegase e fai si ese. Ae, e ui lava i lenei mea, o loo i ai le tele o fualaau faasaina ua faamoemoe e faia ai nei faamai. O se tasi oi latou o le "Mesakol". Faatonuga mo le faaaogāina, ituaiga, manatu faaalia, ma le tau o le tupe o le a tuuina atu i lalo.

O le tuufaatasiga, o le ituaiga faamalologa, afifiina ma le faamatalaga

Fualaau faasaina "Mesakol", toe iloiloga o lea o uiga lava ambiguous, alu i le faatauina atu o se papa mumu-lanu enaena. O i latou o enteric-coated ma maua se pepa lapotopoto ma lenticular.

O le mea autu o le meafaigaluega protrudes mesalazine (5-Asa). I le faaopoopo atu i ai o le fualaau faasaina e aofia ai vaega faaopoopo e pei o māsoā saito, kalisiu dihydrate phosphate, talc faamamaina, cellulose microcrystalline, oxide titanium, hypromellose 2208, silica colloid, povidone K90, sodium māsoā carboxymethyl, o le copolymer acid methacrylic ma methyl methacrylate, oxide uʻamea mumu, macrogol 6000 ma phthalate dibutyl.

Papa "Mesakol" gaosia i alumini faasologa fasi pepa ma ato pepa malo.

pharmacology

Na e iloa o se fualaau oona e faapea "Mesakol"? Faatonuga mo le faaaogaina e faailoa o lenei sui sooupu aneti-inflammatory, o le aafiaga o lea ua faasa i le suʻia ai. O lenei meatotino a le medicament ona o lona tomai e taofiofia le tuufaatasia o leukotrienes ma prostaglandins, ma lipoxygenase neutrophil.

E tatau ona tatou matauina foi slows le fualaau faasaina manatu malaga, phagocytosis ma degranulation o neutrophils, faapea foi immunoglobulin secretion e lymphocytes.

O a isi meatotino maua se fofo "Mesakol", o le tau o lea ua faaalia i lalo? Mesalazine ua gaoioiga antimicrobial mai nisi cocci ma Escherichia coli (i le Colón).

Pharmacokinetics

O le a le tapulaa kinetic fananau papa "Mesakol"? Faatonuga mo le faaaogaina o loo faapea ina ua uma ona faamalolo mai pulega mesalazine le atigi pe a uma e uiga i 115-165 minute, ma ina ua mavae 170-230 minute faataape papa.

Ona o ata tifaga fualaau faasaina iloiloga coated i le 60-80% ua tatalaina i le suʻia ai tele, ma le 15-30% - i le laiti suʻia ai. I lenei tulaga o le mea malosi e oo i le faasalalauina faiga na o se aofaiga e 10% o le inumaga. Mesalazine faasalaga i le plasma e matua maualalo.

Fesootaiga o le elemene malolosi e polotini plasma o le 43%. Manatu a fualaau faasaina ma ona metabolites i le susu o le susu.

faatinoina Metabolism mesalazine i le suʻia ma ate. O lenei e maua N-acetyl-5-aminosalicylic acid.

O le afa o le olaga o le 60-120 minute (e faalagolago i le inumaga). Faaalia vailaau fatugao ma e ala i le loto ona.

Faailoga e maua ai fualaau

Lea feutagaʻi faamai o le fualaau faasaina "Mesakol"? Toe iloiloga o fomai lipoti e lelei faaalia lava lenei meafaigaluega lava i faamaʻi ma colitis ulcerative a Crohn.

E tatau ona matauina ai o loo faaaogaina e le gata i medicament iloiloina mo le togafitia o le faamai ua taʻua i luga ae faapea foi mo le puipuiga o exacerbations.

Contraindications i fualaau

Prescribers "Mesakol" le fautuaina:

• i papala peptic o le faiga digestive;
• faamai toto;
• le atoatoa ogaoga Fatugao;
• diathesis hemorrhagic;
• i le olaga faatamaitiiti;
• faaletonu hepatic ogaoga;
• hypersensitivity i le vaega o le fualaau faasaina;
• leai o dehydrogenase kulukose-6-phosphate.

Ma le faaeteete tele faaaogaina o fualaau oona i le agamalu e feololo mamafa o le toilalo Fatugao, faapea foi ma le atoatoa hepatic feololo ma agamalu.

Papa "Mesakol": faatonuga mo le faaaogaina

O le tupe ave tuufofoga na maea ai o se taumafataga.

I le taimi o exacerbation o faamaʻi o lo o faafoeina i se aofaiga o 400-800 mg (i.e., 1-2 papa) faatolu i le aso. O le togafitiga ua faia mo 9-12 vaiaso.

Mo le puipuiga o exacerbations o le faaaogaina o fualaau oona e 400 mg faatolu i le aso. O le fualaau e masani lava i le tulaga o, vai inu masani.

E faapefea ona e tuuina atu i tamaiti se fualaau faasaina "Mesakol"? Moligao, microclysters ma le faamalolo lē tumau - i lenei pepa ua faaali mai e le fualaau faasaina e tamaiti.

tali matuia

Ae paga lea, le faia o vailaau manatu lava e masani ona mafua ai aafiaga itu. E aofia ai mea nei:

• pericarditis, tachycardia, faaletonu conduction fatu, toto maualuga, tiga o le fatafata, hypotension, palpitations, shortness o le manava;
• faafaufau, faaitiitia le manao, faasuati, faateleina o transaminases ate, manava tīgā, stomatitis, manavatatā, hepatitis, tiga lona manava, pancreatitis, gutu matutu;
• oliguria, proteinuria, crystalluria, hematuria, syndrome nephrotic, anuria;
• dizziness, tiga le ulu, manatu faatupu, tinnitus, moe fiti, polyneuropathy, tete, gatete, i le atuatuvale;
• eosinophilia, thrombocytopenia, anemia (haemolytic, aplastic, po megaloblastic), agranulocytosis, anemia, hypoprothrombinemia;
• oligospermia, le vaivai;
• vaivai, photosensitivity, mumps, faaitiitia le tuuina atu o sua loimata, syndrome lupus-e pei o, alopecia;
• paʻu rashes, dermatitis, pruritus, bronchospasm, erythema.

O auga o inumaga tele naʻuā

O auga inumaga tele naʻuā o lona uiga o manatu protrude tuutuuga e pei o le faafaufau, gastralgia, faasuati, sleepiness ma vaivaiga. Ina ia aveesea i latou ua lavage gastric faatonuina, laxatives ma togafitiga symptomatic.

Ogatasi ma isi oloa

Fualaau faasaina "Mesakol" faaitiitia ai le aafiaga o le "spironolactone" "Furosemide", "rifampicin" ma sulfonamides. E faaleleia ai foi aafiaga hypoglycemic o pogai sulfonylurea, o le toxicity o methotrexate ma corticosteroids ulzerogennosti.

E tatau ona matauina foi slows le fualaau faasaina o le mitiia o cyanocobalamin ma e faateleina ai foi le aafiaga o sui uricosuric (ie, blockers secretion tubular) ma faaleleia ai le aafiaga o anticoagulants.

fautuaga patino

• Manavatatā tutupu taimi o le togafitiga "Mesakolom" E le fiafia i taimi uma le itu i aafiaga o fualaau. e mafai ona avea ma se tulaga o se faailoga o faamaʻi faavae.
• I le taimi o le taliaina, e tatau ona tauaveina e le aunoa o le meafaigaluega mai tofotofoga masani toto ma miaga.
• Afai na misia le inumaga, e tatau ona faia nei i so o se isi lava taimi.
• I le taimi o le togafitiga i lenei vailaau ma e mafai ona lanu le suāvai loimata miaga o le onosai i se lanu moli-samasama.

Fualaau faasaina "Mesakol": counterparts ma le tau

Sui le vailaau fai e mafai ona e ala e pei o le "salazopiridazina", "5-Asa", "Tidokol" "Asacol", "Samezil", "salofalk", "Mesalazine", "Salozinal", "pentasil".

Le a le tele o le "Mesakol" laupapa? O le tau o lenei fualaau faasaina o le 600-680 rubles (50 papa).

tagata faatau iloiloga

Gasegase tuua le "Mesakol" sauniuniga ua lava fefiloi iloiloga. O nisi oi latou lipotia ona feutagaʻi lelei le fualaau faasaina faamaʻi intestinal. Isi finau e aoga nei pills. O lea la, e mafai ona e faaiuina le saogalemu tatou "Mesakol" ei eseese aafiaga i gasegase eseese.

O le drawback autu o lenei fualaau o le vaega tele o contraindications ma tali faigata.