peroxidation Lipid (LPO) o se sootaga taua i le fesuiaiga metabolic. O le galuega tauave autu o le i ai o le faafouina o le lipids o membranes feaveai.
I se peroxidation lipid tagata maloloina pulea e mea ua taʻua o faiga antioxidant lea e faatonutonu ai le gaoioiga saoasaoa ma phosphorylation ala i le fusia faatupu itu po neutralize lava aofaiga o peroxides e taofia se overabundance o oloa faaiuga o metabolism. Atonu o le taimi e amata faagasologa oxidation Amplification i le pathophysiological faagasologa faamai aofaiga taua. O lenei faiga e aofia ai se laasaga o enzymatic ma autoxidation lē enzymatic.
ituaiga
Ina ia suia le bilayer phospholipid o le membrane feaveai faalautele oxidation enzymatic. E le gata i lea, ua aafia i le faavaeina o mea biologically toaaga, detoxification, tali metabolic. oxidation lē enzymatic e faaalia ia lava, o se vaega matautia i le olaga o le sela. Ona o le faavaega o le aofaiga tele o saoloto radicals ma peroxides faaputuga faaitiitia gaoioiga faiga antioxidant ma o se taunuuga, ua i ai le faafanoga o le sela tino.
PAUL taamilosaga
Ina ia amata le afioaga e talafeagai lipid peroxidation o le okesene radicals saoloto, ua i ai le tulaga o le malosi i le ogaoga tasi electron unpaired. Ina ua uma ona toe faaolaina mai o molecules okesene gaosia superoxide lea ona gaoioi ma atoms hydrogen, liliu atu i peroxide hydrogen. Mo le puleaina o le aofaiga o superoxide totonu sela ai superoxide dismutase, fausia hydrogen peroxide ma catalase, peroxidase neutralize i vai. Afai na aafia se tino ola e ionizing leisa, o le aofai o saoloto radicals hydroxyl le a faateleina manino. E lē gata i hydroxide okesene ma ona isi ituaiga toaga ona amatalia le startup faagasologa o lipid peroxidation.
Products o lipid peroxidation po o tino lafoaia, po o le faaaoga mo le tuufaatasia o prostaglandins (vailaau aofia ai i tali pupuga), thromboxanes (aofia thrombogenic cascade o tali), homone adrenal.
faiga pulea
Faalagolago i le saosaoa faavae fausaga membrane feaveai, ma e mafai ona fetuunai le aofaiga o gaoioiga o le taunuuga o oloa oxidation. Mo se faataitaiga, o le gaoioiga o lipids peroxidation i luga pe afai o se vaega o le ua pule ai le puipui feaveai acids puta unsaturated, ma telegegese, pe afai o le faavae o le COP o cholesterol. Gata i lea, o vala pulea le aofaiga ma le fua faatatau o le faavaega o radicals saoloto okesene, faapea foi ma le faaaogāina o peroxides, o enzymes metabolic. E oo lava i le tali mai a lipids peroxidation auai mea e aafia ai le tuufaatasiga lipid membrane feaveai ma suiga soʻona faia e tusa ai ma le manaoga o le tino. E aofia ai le vitamini E ma K, thyroxine (hormone thyroid), hydrocortisone, cortisone ma aldosterone (o ni manatu faaalia). Destabilizing pa feaveai ions uamea, vaitamini C ma D.
solia o le faagasologa
oloa Metabolic o lipid peroxidation mafai faaputuputu i le aano o le tino ma le vai tino sei vagana e le faamatuu faiga antioxidant o latou i le saoasaoa e tatau ai. La motusia felauaiga o ions i le membrane feaveai, lea o le faaalatua e mafai ona aafia ai le tuufaatasiga ionic o le vaega faasuavaia o le toto, o le fua faatatau o polarization ma depolarization o le membrane feaveai maso (solia conduction o uunaiga uaua, latou contractility, prolonging le vaitaimi refractory), faafaigofie ai le ulufale o sua i le va extracellular (edema, clots toto, eseʻesega electrolyte). I le faaopoopo atu, o le oloa autu o lipid peroxidation, ina ua mavae se faasologa o tali biochemical, ua liua i aldehydes, ketones, acids ma isi mea faapena. O nei mea ua i ai le i ai se aafiaga oona tino, lea e iloa lelei lava i le fua faatatau faaitiitiga o tuufaatasia DNA, faateleina capillary permeability, faateleina uunaiga oncotic, e pei o lea, sludge-syndrome.
Faaaliga i le falemaʻi
Talu mai le faateleina o le radicals okesene saoloto ei ai aafiaga leaga i luga o le pa feaveai, ma le oloa metabolic faalavelave i le metabolism ma tuufaatasia o acids nucleic ma mea oona o le tino, latou vaega pathophysiologic i le atinae o le tele o tulaga togafitiga. O le matafaioi a lipid peroxidation i ate o se faamaʻi taua o le sooga, faamai pipisi parasitic, faaletonu hemodynamic, faamai oncological, traumas ma mu. POL o se tasi o vaega mo atherosclerosis. radicals Free oxidize cholesterol ma ona maualalo vaega mamafa molecular e fausia ai oloa e faaleagaina le puipui vascular. O lenei e amata a cascade o pathological tali masani e lauga faaleagaina. O lenei sa faaosoosoina clots toto, faaputuga o clots toto i le lumen o vaa laiti po o le faapipiiina i ai oo latou puipui. O se taunuuga o le faagaioiga o le toto slows i lalo i le nofoaga lenei, e pei ona ua uma ona avea ma se lumen vaa. O lenei sao i le faaputuga nisi o clots toto. Le e sili ona aafia o suiga i le arteries coronary, o le aorta, na faaalia i le auga falemaʻi o faamaʻi coronary o le loto.
faiga e puipuia ai
tatau ona e manatua o Fomai o le faafoeina o taualumaga diagnostic ma togafitiga e mafai ona e faatoaaga ai le faiga o lipid peroxidation. O lenei e tatau ona lapataʻia ma le onosai. E faatupu vala e aofia ai togafitiga i le leisa (mo le kanesa), o le malamalama ultraviolet (faatasi ai ma rickets, faamai inflammatory o le sinuses, antibacterial potu togafitiga), fanua maneta (MRI, CT, togafitiga faaletino) sauniga i se potu hyperbaric (i le poliomyelitis, maʻi maualuga).
Puipuia ma le togafitiga
Tagata faigaluega i rentgenkabinetom, orderlies ma tausimai, faapitoa i physiotherapy, mountaineers, tagata sili atu le mamafa e tatau ona e aai i meaai o loo i ai antioxidants faalenatura: iʻa, sunflower po o le suauu olive, laau, fuamoa, green lauti. I le faaopoopo atu i le suia o le meaai, e mafai ona faaaoga fualaau fusifusia i vaega patino po o radicals saoloto tuufaatasia ma uʻamea o ma liuliuina valency. Sa faapea ona latou tutu saoloto o molecules toaaga okesene, e taofia ai i latou mai noatia e amplifiers lipid peroxidation.
diagnostics
I le tulaga oi ai nei o le atinae o fale suesue o suesuega e mafai ona tatou iloa peroxide i le tuufaatasiga o vai moni o le tino o le tagata. Ina ia faia lenei mea, tauaveina microscopy fluorescence. Faaupuga faigofie, e faailoa le peroxidation lipid. O le taua o lenei suega diagnostic manaomia ai se faamalamalamaga. O le mea moni, i se faamaʻi aofaiga taua faavae o gaoioiga o le tele o lipid peroxidation. Mauaina o lenei tulaga fuafuaina togafitiga.
Mai le vaaiga i le physiology masani o lipid peroxidation e tatau ai mo le faavaeina o homone steroid, o puluvaga inflammatory, cytokines ma thromboxanes. Ae ina ua le aofai o vailaau tali faamatalaga oloa fesuiaiga o tupe e sili atu le taua faatagaina ma peroxide faaleagaina organelles feaveai, DNA ma faalavelave i le tuufaatasia o polotini, i aafiaga ulufale faiga antioxidant e faaitiitia ai le aofaiga o radicals saoloto okesene ma ions o uʻamea ma ma liuliuina valency. I le faaopoopo atu, e faateleina ai le tuufaatasia o catalase ma peroxidase mo le lafoaia o sili peroxides ma oloa o lo latou toe metabolism.